Grupo Frankel
Area de estudio

Evolución y Desarrollo

Dr. Nicolas Frankel
JEFE DE GRUPO

Profesor del Departamento de Ecologia, Genetica y Evolucion, FCEN, UBA
Investigador Independiente CONICET

¿Cómo está codificada la información que regula la expresión génica durante el desarrollo? ¿Cómo evoluciona el ADN regulatorio en los genomas animales?

Lineas de Investigacion:

Estructura y función de enhancers pleiotrópicos en genomas animales
Arquitectura de la red regulatoria del gen shavenbaby en distintos contextos del desarrollo de D.melanogaster
  • Grupo Frankel
  • Grupo Frankel
• Publicaciones (desde 2010)

Kittelmann S, Preger-Ben Noon E, McGregor AP, Frankel N. A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila. Current Opinion in Genetics and Development (2021) 69:21-27.

 

Soverna AF, Rodriguez NC, Korgaonkar A, Hasson E, Stern DL, Frankel N. Cis-regulatory variation in the shavenbaby gene underlies intraspecific phenotypic variation, mirroring interspecific divergence in the same trait. Evolution (2021) 75:427-436.

 

Sabarís G, Laiker I, Preger-Ben Noon E, Frankel N. Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity. Trends in Genetics (2019) 35:423‐433.

 

Kittelmann S, Buffry AD, Franke FA, Almudi I, Yoth M, Sabaris G, Couso JP, Nunes MDS, Frankel N, Gómez-Skarmeta JL, Pueyo-Marques J, Arif S, McGregor AP. Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution. PLoS Genetics (2018) 14:e1007375.

 

Preger-Ben Noon E*, Sabarís G*, Ortiz DM, Sager J, Liebowitz A, Stern DL, Frankel N. Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function. Cell Reports (2018) 22:3021-3031.

 

Stern DL, Crocker J, Ding Y, Frankel N, Kappes G, Kim E, Kuzmickas R, Lemire A, Mast JD, Picard S. Genetic and Transgenic Reagents for Drosophila simulans, D. mauritiana, D. yakuba, D. santomea, and D. virilis. G3 (2017) 7:1339-1347.

 

Colines B, Rodríguez NC, Hasson ER, Carreira V, Frankel N. Parental age influences developmental stability of the progeny in Drosophila. Proceedings of the Royal Society B (2015) 282. pii: 20142437.

 

Preger-Ben Noon E, Frankel N. Evolving genital structures: a deep look at network co-option. Developmental Cell (2015). 34:485-6

 

Crocker J, Abe N, Rinaldi L, McGregor AP, Frankel N, Wang S, Alsawadi A, Valenti P, Plaza S, Payre F, Mann RS, Stern DL. Low affinity binding site clusters confer hox specificity and regulatory robustness. Cell (2015)160:191-203.

 

Stern DL, Frankel N. The structure and evolution of cis-regulatory regions: the shavenbaby story. Philosophical Transactions of the Royal Society B (2013) 368:20130028.

 

Domínguez PG, Frankel N, Mazuch J, Balbo I, Iusem N, Fernie AR, Carrari F. ASR1 mediates glucose-hormone crosstalk by affecting sugar trafficking in tobacco plants. Plant Physiology (2013) 161:1486-500.

 

Frankel N, Wang S, Stern DL. Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution. Proceedings of the National Academy of Sciences USA (PNAS) (2012) 109(51):20975-9.

 

Frankel N. Multiple layers of complexity in cis-regulatory regions of developmental genes. Developmental Dynamics (2012) 241:1857-66.

 

Frankel N*, Erezyilmaz DF*, McGregor AP, Wang S, Payre F, Stern DL. Morphological evolution caused by many subtle-effect substitutions in a transcriptional enhancer. Nature (2011) 474:598–603.

 

Frankel N, Davis GK, Vargas D, Wang S, Payre F, Stern DL. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature (2010) 466:490-493. 

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Integrantes del grupo

Daniela Ortiz

Daniela Ortiz

Becaria Doctoral

foto Ian

Ian Laiker

Becario Doctoral

CamScanner 04-23-2021 19.10

Martin Saraceno

Becario Doctoral

foto Nacho

Ignacio Mayansky

Becario doctoral

Miembros Anteriores

Dr. Gonzalo Sabarís

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