Dr. Alberto Kornblihtt
Profesor Titular Plenario, FCEN, UBA.
Investigador Superior (CONICET)
Título/s: Doctor de la Universidad de Buenos Aires
Licenciado en Ciencias Biológicas
– Maslon, M. M., Braunschweig, U., Aitken, S., Mann, A. R., Kilanowski, F., Hunter, C. J., Blencowe, B. J., Kornblihtt, A. R., Adams, I. R. & Cáceres, J. F.
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes.
EMBO Journal (2019) In press.
– Godoy Herz, M. A., Kubaczka, M. G., Brzyzek, G., Servi, L., Krzyszton, M., Simpson, C., Brown, J., Swiezewski, S., Petrillo, E. & Kornblihtt, A. R.
Light regulates plant alternative splicing through the control of transcriptional elongation.
Molecular Cell (2019) 73, 1066-1074.
– Muñoz*, M. J., Nieto Moreno*, N., Giono*, L. E., Cambindo Botto, A. E., Dujardin, G., Bastianello, G., Lavore, S., Torres-Méndez, A., Menck, C. F. M., Blencowe, B., Irimia, M., Foiani, M. & Kornblihtt, A. R.
Major roles of cyclobutane pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation.
Cell Reports (2017) 12, 2868-2879.
– Fiszbein, A., Giono, L.E., Quaglino, A., Berardino, B. G., Singaut, L., von Bildering, C., Schor, I. E., Pietrasanta, L., Caramelo, J., Srebrow, A. & Kornblihtt, A. R.
Alternative splicing of G9a regulates neuronal differentiation
Cell Reports (2016) 14, 2797–2808
– Agirre*, E., Bellora*, N., Alló*, M., Pagès, A., Bertucci, P., Kornblihtt, A. R. & Eyras, E.
A chromatin code for alternative splicing involving a putative association between CTCF and HP1α proteins
BMC Biology (2015) 13, 31
– Buggiano, V., Petrillo, E., Alló, M., Lafaille, C., Redal, M. A., Alghamdi, M. A., Khoder, M. I., Shamy, M., Muñoz, M. & Kornblihtt, A. R.
Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells
Environmental Research (2015) 140, 185-190
– Alló*, M., Agirre*, E., Bessonov*, S., Bertucci*, P., Gómez Acuña*, L., Buggiano, V., Bellora, N., Singh, B., Petrillo, E., Blaustein, M., Miñana, B., Dujardin, G., Pozzi, B., Pelisch, F., Bechara, E., Agafonov, D. E., Srebrow, A., Lührmann, R., Valcárcel, J., Eyras, E.* & Kornblihtt, A. R.*
Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells
Proc. Natl. Acad. Sci. USA (2014) 111, 15622-15629.
– Petrillo, E., Godoy Herz, M. A., Simpson, C., Fuller, J., Yanovsky, M. J., Fuchs, A., Brown, J. W. S., Barta, A., Kalyna, M. & Kornblihtt, A. R.
A chloroplast retrograde signal regulates nuclear alternative splicing
Science (2014) 344, 427-430
– Dujardin, G., Lafaille, C., de la Mata, M., Marasco, L., Muñoz, M. J., Le Jossic-Corcos, C., Corcos, L. & Kornblihtt, A. R.
How slow RNA Polymerase II elongation favors alternative exon skipping
Molecular Cell (2014) 54, 683-690
– Bielli, P., Busà, R., Di Stasi, S. M., Muñoz, M. J., Botti, F., Kornblihtt, A. R. & Sette C.
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis.
EMBO Reports (2014) 15, 419-427
– Schor, I. E., Fiszbein, A., Petrillo, E. & Kornblihtt, A. R.
Intragenic epigenetic changes modulate NCAM alternative splicing upon neuronal differentiation
EMBO J. (2013) 32, 2264-2274
– Schor, I. E., Llerès, D., Risso, G., Pawellek, A., Ule, J., Lamond, A. & Kornblihtt, A. R.
Perturbation of chromatin structure globally affects localization and recruitment of splicing factors
PLoSOne (2012) 7, e48084
– de la Mata, M., Lafaille, C. & Kornblihtt, A. R.
First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal.
RNA (2010) 16, 905-912
– Sánchez*, S. E., Petrillo*, E., Beckwith, E. J., Zhang, X., Matías, L., Rugnone, C., Hernando, E., Cuevas, J. C., Godoy Herz, M. A., De Petris-Chauvin, A., Simpson, C. G., Brown, J. W. S., Cerdán, P. D., Borevitz, J. O., Mas, P., Ceriani, M. F., Kornblihtt, A. R. & Yanovsky, M. J.
A methyl transferase links the circadian clock to the regulation of transcription and alternative splicing.
Nature (2010) 468, 112-116
– Muñoz, M. J., Pérez Santangelo, M. S., Paronetto, M. P., de la Mata, M., Pelisch, F., Boireau, S., Glover-Cutter, K., Ben-Dov, C., Blaustein, M., Lozano, J. J., Bird, G., Bentley, D., Bertrand, E. & Kornblihtt, A. R.
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.
Cell (2009) 137, 708-720. Commented as Leading Edge in Cell 137, 600-602 (2009)
– Schor, I. E., Rascovan, N., Pelisch, F., Alló, M. & Kornblihtt, A. R.
Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing.
Proc. Natl. Acad. Sci. USA. (2009) 106, 4325-4330
– Alló, M., Buggiano, V., Fededa, J. P., Petrillo, E., Schor, I., de la Mata, M., Agirre, E., Plass, M., Eyras, E., Abou Elela, S., Klinck, R., Chabot, B. & Kornblihtt, A. R.
Control of alternative splicing through siRNA-mediated transcriptional gene silencing.
Nature Struct. Mol. Biol. (2009) 16, 717-724
– de la Mata, M. & Kornblihtt, A. R.
RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20.
Nature Struct. Mol. Biol. (2006) 13, 973-980 (Commented as News and Views in Nature Struct. Mol. Biol. 13, 952-953, 2006. Selected in Faculty of 1000).
– Fededa, J. P., Petrillo, E., Gelfand, M. S., Neverov, A. D., Kadener, S., Nogués, G., Pelisch, F., Baralle, F. E., Muro, A. F., and Kornblihtt, A. R.
A polar mechanism coordinates different regions of alternative splicing within a single gene.
Molecular Cell (2005) 19, 393-404
– de la Mata, M., Alonso, C. R., Kadener, S., Fededa, J. P., Blaustein, M., Pelisch, F., Cramer, P., Bentley, D., & Kornblihtt, A. R.
A slow RNA polymerase II affects alternative splicing in vivo.
Molecular Cell (2003) 12, 525-532 (Commented as News and Views in Nature Struct. Mol. Biol. 10, 876-878 (2003). Selected as “exceptional” (factor 9) in Fac)
– Kadener, S., Fededa, J. P., Rosbash, M. & Kornblihtt, A. R.
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation.
Proc. Natl. Acad. Sci. USA (2002) 99, 8185-8190 (Selected as “must read” (factor 3) in Faculty of 1000).
– Kadener, S., Cramer, P., Nogués, G., Cazalla, D., de la Mata, M., Fededa, J. P., Werbajh, S., Srebrow, A. & Kornblihtt, A. R.
Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing.
EMBO J. (2001) 20, 5759-5768
– Cramer, P., Cáceres, J., Cazalla, D., Kadener, S., Muro, A. F., Baralle, F. E. & Kornblihtt, A. R.
Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer.
Molecular Cell (1999) 4, 251-258
– Melen, G. J., Pesce, C. G., Rossi, M. S. & Kornblihtt, A. R.
Novel processing in a mammalian nuclear 28S pre-rRNA: tissue-specific elimination of an “intron” bearing a hidden break site.
EMBO J. (1999) 18, 3107-3118
– Cramer, P., Pesce, C. G., Baralle, F. E. & Kornblihtt, A. R.
Functional association between promoter architecture and transcript alternative splicing.
Proc. Natl. Acad. Sci. USA (1997) 94,, 11456-11460
– Alonso, C. R., Pesce, C. G. & Kornblihtt, A. R.
The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene.
J. Biol. Chem. (1996) 271, 22271-22279
– Lavigueur, A., La Branche, H., Kornblihtt, A. R. & Chabot, B.
A splicing enhancer in the human fibronectin alternate ED1 exon stimulates the binding of U2AF65 and U2 snRNP.
Genes & Dev. (1993) 7, 2405-2417
– Muro, A. F., Bernath, V. A. & Kornblihtt, A. R.
Interaction of the -170 Cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter.
J. Biol. Chem. (1992) 267, 12767-12774
– Bernath, V. A., Muro, A. F., Vitullo, A. D., Bley, M. A., Barañao, J. L. & Kornblihtt, A. R.
Cyclic AMP inhibits fibronectin gene expression in a newly developed granulosa cell line by a mechanism that suppresses cAMP-responsive-element transcriptional activation.
J. Biol. Chem. (1990) 265, 18219-18226
– Gutman, A. & Kornblihtt, A. R.
Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA.
Proc. Natl. Acad. Sci. USA (1987) 84, 7179-7182
– Kornblihtt, A. R., Umezawa, K., Vibe-Pedersen, K. & Baralle, F. E.
Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.
EMBO J. (1985) 4, 1755-1759
– Kornblihtt, A. R., Vibe-Pedersen, K. & Baralle, F. E.
Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain.
EMBO J. (1984) 3, 221-226
– Kornblihtt, A. R., Vibe-Pedersen, K. & Baralle, F. E.
Isolation and characterization of cDNA clones for human and bovine fibronectins.
Proc. Natl. Acad. Sci. USA (1983) 80, 3218-3222