¿Cómo está codificada la información que regula la expresión génica durante el desarrollo? ¿Cómo evoluciona el ADN regulatorio en los genomas animales?
Lineas de Investigacion:
Kittelmann S, Preger-Ben Noon E, McGregor AP, Frankel N. A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila. Current Opinion in Genetics and Development (2021) 69:21-27.
Soverna AF, Rodriguez NC, Korgaonkar A, Hasson E, Stern DL, Frankel N. Cis-regulatory variation in the shavenbaby gene underlies intraspecific phenotypic variation, mirroring interspecific divergence in the same trait. Evolution (2021) 75:427-436.
Sabarís G, Laiker I, Preger-Ben Noon E, Frankel N. Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity. Trends in Genetics (2019) 35:423‐433.
Kittelmann S, Buffry AD, Franke FA, Almudi I, Yoth M, Sabaris G, Couso JP, Nunes MDS, Frankel N, Gómez-Skarmeta JL, Pueyo-Marques J, Arif S, McGregor AP. Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution. PLoS Genetics (2018) 14:e1007375.
Preger-Ben Noon E*, Sabarís G*, Ortiz DM, Sager J, Liebowitz A, Stern DL, Frankel N. Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function. Cell Reports (2018) 22:3021-3031.
Stern DL, Crocker J, Ding Y, Frankel N, Kappes G, Kim E, Kuzmickas R, Lemire A, Mast JD, Picard S. Genetic and Transgenic Reagents for Drosophila simulans, D. mauritiana, D. yakuba, D. santomea, and D. virilis. G3 (2017) 7:1339-1347.
Colines B, Rodríguez NC, Hasson ER, Carreira V, Frankel N. Parental age influences developmental stability of the progeny in Drosophila. Proceedings of the Royal Society B (2015) 282. pii: 20142437.
Preger-Ben Noon E, Frankel N. Evolving genital structures: a deep look at network co-option. Developmental Cell (2015). 34:485-6
Crocker J, Abe N, Rinaldi L, McGregor AP, Frankel N, Wang S, Alsawadi A, Valenti P, Plaza S, Payre F, Mann RS, Stern DL. Low affinity binding site clusters confer hox specificity and regulatory robustness. Cell (2015)160:191-203.
Stern DL, Frankel N. The structure and evolution of cis-regulatory regions: the shavenbaby story. Philosophical Transactions of the Royal Society B (2013) 368:20130028.
Domínguez PG, Frankel N, Mazuch J, Balbo I, Iusem N, Fernie AR, Carrari F. ASR1 mediates glucose-hormone crosstalk by affecting sugar trafficking in tobacco plants. Plant Physiology (2013) 161:1486-500.
Frankel N, Wang S, Stern DL. Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution. Proceedings of the National Academy of Sciences USA (PNAS) (2012) 109(51):20975-9.
Frankel N. Multiple layers of complexity in cis-regulatory regions of developmental genes. Developmental Dynamics (2012) 241:1857-66.
Frankel N*, Erezyilmaz DF*, McGregor AP, Wang S, Payre F, Stern DL. Morphological evolution caused by many subtle-effect substitutions in a transcriptional enhancer. Nature (2011) 474:598–603.
Frankel N, Davis GK, Vargas D, Wang S, Payre F, Stern DL. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature (2010) 466:490-493.
-
noticias frankel
28/10/2019 Noticias / Medios - Frankel
Integrantes del grupo

Daniela Ortiz
Becaria Doctoral

Daniela Ortiz
Becaria Doctoral
- Phone:+549 (11) 2546-6589
- Email:info@example.com

Ian Laiker
Becario Doctoral

Ian Laiker
Becario Doctoral
- Phone:+549 (11) 2546-6589
- Email:info@example.com

Martin Saraceno
Becario Doctoral

Martin Saraceno
Becario Doctoral
- Phone:+549 (11) 2546-6589
- Email:info@example.com

Ignacio Mayansky
Becario doctoral

Ignacio Mayansky
Becario doctoral
- Phone:+549 (11) 2546-6589
- Email:info@example.com

Nicolas Portnoy
Estudiante

Nicolas Portnoy
Estudiante
- Phone:+549 (11) 2546-6589
- Email:info@example.com

Ailen Altamirano
Estudiante

Ailen Altamirano
Estudiante
- Phone:+549 (11) 2546-6589
- Email:info@example.com
Miembros Anteriores
Dr. Gonzalo Sabarís