publicaciones

  • Unraveling the Molecular Interactions Involved in Phase Separation of Glucocorticoid Receptor. Martin Stortz, Adali Pecci, Diego Presman✉, and Valeria Levi✉. BMC Biology, 2020, 18(1):59. https://doi.org/10.1186/s12915-020-00788-2. ✉co-corresponding authors.
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  • Glucocorticoid Receptor Quaternary Structure Drives Chromatin Occupancy and Transcriptional Outcome. Ville Paakinaho, Thomas A. Johnson, Diego M. Presman✉, Gordon L. Hager✉. Genome Research, 2019 Aug;29(8):1223-1234. https://doi.org/10.1101/gr.244814.118. ✉co-corresponding authors. Destacada en F1000.
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  • Assaying Homodimers of NF-κB in Live Single Cells. Erik W. Martin, Sayantan Chakraborty, Diego M. Presman, Francesco Tomassoni Ardori, Kyu-Seon Oh, Mary Kaileh, Lino Tessarollo, Myong-Hee Sung. Frontiers Immunology 2019, Nov 07 10, 2609. https://doi.org/10.3389/fimmu.2019.02609.
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  • The Glucocorticoid Receptor Interferes with Progesterone Receptor-Dependent Genomic Regulation in Breast Cancer Cells. Maria Florencia Ogara, Santiago A. Rodríguez-Seguí, Melisa Marini, A. Silvina Nacht, Martin Stortz, Valeria Levi, Diego M. Presman, Guillermo P. Vicent and Adali Pecci. Nucleic Acid Research 2019, Oct 10. pii: gkz857. https://doi.org/10.1093/nar/gkz857.
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  • Meta-analysis of Chromatin Programming by Steroid Receptors. Ville Paakinaho, Erin E. Swinstead, Diego M. Presman, Lars Grøntved, and Gordon L. Hager. Cell Reports 2019, Sept 24 28(13): 3523-3534. https://doi.org/10.1016/j.celrep.2019.08.039
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  • Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility. Diana A. Stavreva, David A. Garcia, Gregory Fettweis, Prabhakar R. Gudla, George F. Zaki, Vikas Soni, Andrew McGowan, Geneva Williams, Anh Huynh, Murali Palangat, R. Louis Schiltz, Thomas A. Johnson, Diego M. Presman, Matthew L. Ferguson, Gianluca Pegoraro, Arpita Upadhyaya, and Gordon L. Hager. Molecular Cell, 2019 Jul 26. pii: S1097-2765(19)30499-X. https://doi.org/10.1016/j.molcel.2019.06.042.
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  • Single-cell resolution and quantitation of targeted glucocorticoid delivery in the thymus. Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell. Cell Reports, 2019, 26(13):3629-3642.e4. https://doi.org/10.1016/j.celrep.2019.02.108.
  • 21-hydroxy-6,19-epoxyprogesterone: a Promising Therapeutic Agent and a Molecular Tool for Deciphering Glucocorticoid Action. Pecci, A, Alvarez, L.D., Presman, D.M., Burton, G. Minireviews in Medicinal Chemistry 2018. 18(5):428-438. https://doi.org/10.2174/1389557516666160118112313.
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  • More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? Presman, D.M✉., Hager, G.L. Transcription, 2017. 8:1, 32-39. https://doi.org/10.1080/21541264.2016.1249045. ✉corresponding author.
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  • Single-molecule Analysis of Glucocorticoid Receptor and Cofactor Action in Living Cells. Paakinaho, V., Presman, D.M., Ball, D., Johnson, T.A., Schiltz, R.L., Levitt, P., Mazza, D., Morisaki, T., Karpova, T.S., Hager, G.L. Nature Communications 2017, Jun 21;8:15896. https://doi.org/10.1038/ncomms15896. *co-first authors. Destacada en F1000.
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  • Quantifying Transcription Factor Binding Dynamics at the Single-molecule Level in Live Cells. Presman, D.M., Ball, D., Paakinaho, V*., Grimm, J.B., Lavis, L.D. Karpova, T.S., Hager, G.L. Methods 2017. pii: S1046-2023(16)30450-9. https://doi.org/10.1016/j.ymeth.2017.03.014. *co-first authors.
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  • Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output. Álvarez LD, Presman DM, Pecci A. PLoS One. 2017 Dec 15;12(12):e0189588. https://doi.org/10.1371/journal.pone.0189588.
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  • Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape. Stortz M, Presman DM, Bruno L, Annibale P, Dansey MV, Burton G, Gratton E, Pecci A, Levi V. Sci Rep. 2017, 7(1):6219. https://doi.org/10.1038/s41598-017-06676-0
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  • Transcription factor assisted loading and enhancer dynamics dictate the fasting response. Goldstein, I., Baek, S., Presman, D.M., Paakinaho, V., Swinstead, E.E, Hager, G.L. Genome Research, 2017. (3):427-439. https://doi.org/10.1101/gr.212175.116
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  • DNA-binding Triggers Tetramerization of the Glucocorticoid Receptor in Live Cells. Presman, D.M✉, Ganguly, S., Schiltz, R.L., Johnson, T.A., Karpova, T.S., Hager, G.L✉. Proc Natl Acad Sci USA, 2016 113 (29) 8236-8241. ✉co-corresponding authors. https://doi.org/10.1073/pnas.1606774113
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  • Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective. Swinstead, E.E., Paakinaho, V., Presman, D.M., Hager, G.L. Bioessays 2016, 38(11):1150-1157. https://doi.org/10.1002/bies.201600137
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  • Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions. Swinstead, E.E., Miranda, T.B., Paakinaho, V., Baek, S., Goldstein, I., Hawkins, M., Karpova, T.S., Ball, D., Mazza, D., Lavis, L.D., Grimm, J.B., Morisaki, M., Grøntved, L., Presman, D.M., and Hager, G.L. Cell, 2016, 165:593-605. Destacada en F1000. https://doi.org/10.1016/j.cell.2016.02.067
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  • Role of 3′-5′-cyclic adenosine monophosphate on the epidermal growth factor dependent survival in mammary epithelial cells. Grinman, D.Y, Romorini, L., Presman, D.M., Rocha-Viegas, L., Coso, O.A., Davio, C., Pecci, A. Mol Cell Endocrinol. 2015. 419:259-67. *co-first author. https://doi.org/10.1016/j.mce.2015.10.026
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  • Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP. Muratcioglu, S., Presman, D.M, Pooley, J.R, Grøntved, L., Hager, G.L., Nussinov, R., Keskin, O., Gursoy, A. Biophys J. 2015; 109(6):1227-39. *co-second authors. Destacada como “Best of 2015 re-print issue of Biophysical Journal”. https://doi.org/10.1016/j.bpj.2015.06.044
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  • Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor. Presman, D.M., Ogara, M.F, Stortz, M., Alvarez, L.D., Pooley, J.R., Schiltz, R.L, Grøntved, L., Johnson, T.A., Mittelstadt, P.R., Ashwell, J.D., Ganesan, S., Burton, G., Levi, V., Hager, G.L., Pecci, A. PLoS Biology 2014 ;12(3):e1001813. Destacada en F1000. https://doi.org/10.1371/journal.pbio.1001813
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  • Melatonin inhibits glucocorticoid-dependent GR-TIF2 interaction in newborn hamster kidney (BHK) cells. Presman, D.M., Levi, V., Pignataro, O.P., Pecci, A. Mol Cell Endocrinol. 2012; 349(2):214-21. https://doi.org/10.1016/j.mce.2011.10.026
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  • Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids. Presman, D.M, Alvarez, L.D., Levi, V., Eduardo, S., Digman, M.A., Martí, M.A., Veleiro, A.S., Burton, G., Pecci, A. PLoS One. 2010; 5(10):e13279. https://doi.org/10.1371/journal.pone.0013279
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  • Exploring the molecular basis of action of the passive antiglucocorticoid 21-hydroxy-6,19-epoxyprogesterone. Alvarez, L.D., Martí, M.A., Veleiro, A.S., Presman, D.M., Estrin, D.A., Pecci, A., Burton, G. J Med Chem. 2008; 51(5):1352-60. https://doi.org/10.1021/jm800007w
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  • Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Presman, D.M., Hoijman, E., Ceballos, N.R., Galigniana, M.D., Pecci, A. Endocrinology. 2006; 147(11):5452-9. https://doi.org/10.1210/en.2006-0252

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