Dra. Adali Pecci
Profesora Asociada, Departamento de Química Biológica, FCEN, UBA.
Investigadora principal CONICET
Normal 0 21 false false false ES-AR X-NONE X-NONE
PUBLICACIONES
CON ARBITRAJE INTERNACIONAL (últimos 5 años)
64. Dansey MV, Palavecino Ruiz MD, Ogara MF, Pecci A, Burton G, Alvarez LD. Insights into estrogen receptor alpha modulation by cholestenoic acids. J Steroid Biochem Mol Biol. 2021 Dec 14;217:106046. doi: 10.1016/j.jsbmb.2021.106046.
63. F Marceca, L Rocha-Viegas, N Pregi, G Barbas, D Hozbor, A Pecci, R Etchenique. Pool Strategy for Surveillance Testing of SARS-CoV-2. 2021. Sci. Reviews from the end of the world. Vol. 2, No. 2, April 2021 // pp. 42-55.
62. Ambrosis NM, Aispuro PM, Belhart K, Bottero D, Crisp RL, Dansey MV, Gabrielli M, Filevich O, Genoud V, Giordano A, Lin MC, Lodeiro AR, Marceca F, Pregi N, Remes Lenicov F, Rocha-Viegas L, Rudi E, Solovey G, Zurita ME, Pecci A, Etchenique R, Hozbor DF. Active surveillance of asymptomatic, presymptomatic, and oligosymptomatic SARS-CoV-2-infected individuals in communities inhabiting closed or semi-closed institutions. Frontiers in Medicine. 2021 (en prensa).
61. Stortz M, Pecci A, Presman DM, Levi V. Phasing the intranuclear organization of steroid hormone receptors. Biochemical Journal (2021) 478 443–461. https://doi.org/10.1042/BCJ20200883
60. Stortz M, Pecci A, Presman DM, Levi V. Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor. BMC Biology. 2020 20; 18:59doi: 10.1186/s12915-020-00788-2
59. Alvarez LD, Dansey MV, Ogara MF, Peña CI, Houtman R, Veleiro AS, Pecci A, Burton G. Cholestenoic acid analogues as inverse agonists of the liver X receptors. J Steroid Biochem Mol Biol. 2020 Jan 10;199:105585. doi: 10.1016/j.jsbmb.2020.105585.
58. Rocha-Viegas L, Silbermins M; Ogara MF, Pellegrini JM, Nuñez SY, García VE, Vicent GP and Pecci A. Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms. Biochim Biophys Acta Gene Regul Mech. 2020 Jan;1863(1):194475. doi: 10.1016/j.bbagrm.2019.194475
57. Alves, NC, Pecci, A, Alvarez, L. Structural insights into the ligand binding domain of the glucocorticoid receptor: a molecular dynamics study. Journal of Chemical Information and Modeling. 2020 Feb 24;60(2):794-804. doi: 10.1021/acs.jcim.9b00776. Epub 2019 Nov 14.
56. Ogara MF, Rodríguez-Seguí SA, Marini M, Nacht AS, Stortz M, Levi V, Presman DM, Vicent GP, Pecci A. The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells. Nucleic Acids Res. 2019 Oct 10. pii: gkz857. doi: 10.1093/nar/gkz857.
55. Alvarez LD, Pecci A. Mapping the neurosteroid binding sites on glycine receptors. J Steroid Biochem Mol Biol. 2019 Jun 6;192:105388. doi: 10.1016/j.jsbmb.2019.105388.
54. Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X Receptor α Activation Enhances Cholesterol Secretion in Lactating Mammary Epithelium. Am J Physiol Endocrinol Metab. 2019 Apr 9. doi: 10.1152/ajpendo.00548.2018.
53. Leonardi DB, Anselmino N, Brandani JN, Jaworski FM, Páez AV, Mazaira G, Meiss RP, Nuñez M, Nemirovsky SI, Giudice J, Galigniana MD, Pecci A, Gueron G, Vazquez ES, Cotignola J. Heme oxygenase 1 impairs glucocorticoid receptor activity in prostate. Int J Mol Sci. 2019 Feb 26;20(5). pii: E1006. doi: 10.3390/ijms20051006.
52. Alvarez LD, Pecci A, Estrin DA. In Search of GABAA Receptor´s Neurosteroid Binding Sites. J Med Chem. 2019 Jun 13;62(11):5250-5260. doi: 10.1021/acs.jmedchem.8b01400.
51. Alvarez LD, Pecci A. Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor. J Steroid Biochem Mol Biol. 2018 Apr 26. pii: S0960-0760(18)30142-0. doi: 10.1016/j.jsbmb.2018.04.012.
50. Martínez MD, Ghini AA, Dansey MV, Veleiro AS, Pecci A, Alvarez LD, Burton G. Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors. Bioorg Med Chem. 2018 Mar 1;26(5):1092-1101. doi: 10.1016/j.bmc.2018.01.025.
49. Stortz M, Angiolini J, Mocksos E, Wolosiuk A, Pecci A and Levi V. Mapping the dynamical organization of the cell nucleus through fluorescence correlation spectroscopy. Methods 2017 Dec 15. pii: S1046-2023(17)30223-2. doi: 10.1016/j.ymeth.2017.12.008.
48. Alvarez LD, Presman DM and Pecci A. Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain suggest a role of the lever-arm mobility in transcriptional output. Plos One 2017. 12(12):e0189588. DOI: 10.1371/journal.pone.0189588.
47. Stortz M, Presman DM, Bruno L, Annibale P, Dansey MV, Burton G, Gratton E, Pecci* A and Levi* V (*autoras correspondientes) Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape. Scientific Reports, 2017. 7(1):6219-6231 DOI: 10.1038/s41598-017-06676-0
46. Rodriguez CR; Alvarez LD; Dansey MV; Paolo LS; Veleiro AS; Pecci A and Burton G. Fluorinated oxysterol analogues: synthesis, molecular modelling and LXRß activity. J of Steroid Biochemistry and Mol Biology. 2017 165(Pt B):268-276. DOI: 10.1016/j.jsbmb.2016.07.001
PARTICIPACIÓN EN CONGRESOS
• COMUNICACIONES A CONGRESOS INTERNACIONALES (últimos 5 años)
1. WBDS (Women in Bioinformatics & Data Sciences) 2020, 21-24/Set, Buenos Aires, Argentina. Oligopy, a phyton module to determine the oligomerization state of
nuclear particles in images from live cells. Olszanowski Evelyn, Presman Diego Martín and Pecci Adali.
2. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. Glucocorticoid-receptor molecular mechanisms controlling pancreas development and endocrine cell specification. Silvio A. Traba, José García-Bernardo, Mariya Chatriwala, Adali Pecci , Ludovic Vallier, Santiago A. Rodríguez-Seguí.
3. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. Cholestenoic Acid Analogues as Inverse Agonists of the Liver X Receptor. Alvarez, L.D; Dansey, M.V; Peña, C.I; Veleiro, A.S; Pecci, A; Burton, G
4. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. STUDY OF THE JOINT ACTION OF STEROID HORMONE RECEPTORS IN THE MECHANISMS THAT CONTROL INFLAMMATORY RESPONSE. Mariana Noto Guillen, Adali Pecci, María Florencia Ogara
5. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. DYNAMICAL ORGANIZATION OF THE GLUCOCORTICOID RECEPTOR IN DISCRETE NUCLEAR FOCI. Stortz, M; Presman, D; Gratton, E; Levi, V; Pecci, A
6. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. Role of Glucocorticoid Receptor in Myeloid Leukemia Cell Differentiation Induced by Retinoic Acid. Silbermins M, Pecci A, Rocha Viegas L
7. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. Exploring the molecular basis of the Glucocorticoid Receptor-Cofactor interaction. Alves, N.R.C Pecci, A, Alvarez, L.D
8. SISTAM 2018, 2018, 14-19/Oct, Bariloche, Argentina. Novel LXR/ER modulator as a polypharmacological agent against Breast Cancer. Palavecino Ruiz, M. D., Amado, L. D. Medrano, P Burton, G, Pecci, A, Dansey M. V
9. Gordon Research Conferences in Mammary Gland Biology, 2017, Jun/11-16, Stowe VT, USA. Liver X Receptor alpha; Activation Increases Cholesterol Abundance In Mouse Milk. Grinman DG, Rudolph, M, Careaga, VP, Maier MS, Kordon E., Maclean, PS, and Pecci A.
COMUNICACIONES A CONGRESOS NACIONALES (últimos 5 años)
1. LXXI Reunion Anual de SAIC, noviembre 2021. Cooperation between Glucocorticoid and Retinoic Receptos on transcriptional regulation enhances differentiation in
acute myeloid leukemia. Silbermins M, Olszanowski E, Teater M, Meydan C, Duy C, Pecci A, Melnick A y Rocha Viegas L.
2. LXIX Reunion Anual de SAIC, noviembre 2019. Mar del Plata. Involvement of LXR ligands in controlling proliferation of mammary epithelial cells. M Radice, Pecci, A., Dansey M.V, Ogara M.F.
3. XLVIII Reunión Anual de la Sociedad Argentina de Biofísica. Universidad Nacional de San Luis. San Luis. 27-29 de noviembre de 2019. Asistencia a congreso y presentación de póster STRUCTURAL INSIGHTS INTO THE LIGAND BINDING DOMAIN OF THE GLUCOCORTICOID RECEPTOR: A MOLECULAR DYNAMICS STUDY. Alves,N.R.C¹, Pecci, A., Alvarez, L.D.
4. LXIX Reunion Anual de SAIC, noviembre 2019. Mar del Plata. Transcriptional regulation in whole organ mammary gland culture mediated by the Liver X Receptor. E. Olszanowski, DY. Grinman, A Pecci.
5. LXIII Reunion Anual de SAIC, noviembre 2018. Mar del Plata. FUNCTIONAL CROSS-TALK BETWEEN THE GLUCOCORTICOID AND PROGESTERONE RECEPTORS IN MAMMARY EPITHELIAL CELLS. M. Marini, MF. Ogara, GP. Vicent, V Levi, A Pecci
6. Reunión conjunta de Sociedades Biomédicas, noviembre 2017. Buenos Aires. Exploring binding interactions in living cells through advanced fluorescence microscopy and numerical simulations. Stortz MD, Levi V y Pecci A.
7. Reunión conjunta de Sociedades Biomédicas, noviembre 2017. Buenos Aires. Study of the joint action of steroid hormones receptors in the mechanisms that control inflammatory response. Noto M, Pecci A and Ogara MF.
8. Reunión conjunta de Sociedades Biomédicas, noviembre 2017. Analysis of the interaction between the glucocorticoid and the progesterone receptors. Marini, M; Ogara M.F; Stortz M; Levi V; Pecci A.
9. Reunión conjunta de Sociedades Biomédicas, noviembre 2017. Role of glucocorticoids in myeloid leukemia cell differentiation induced by retinoic
acid. Silbermins M, Pecci A and Rocha-Viegas L.