CV
Dra. Amaicha Mara Depino
Profesora Adjunta, Departamento de Biodiversidad y Biología Experimental, FCEN, UBA.
Investigadora Independiente CONICET
Datos académicos
Licenciada en Ciencias Biológicas (1999), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires.
Doctora de la Universidad de Buenos Aires (2003).
Postdoctorado (2004-2006) en el European Molecular Biology Laboratory, Monterotondo, Italia.
Artículos
En revistas internacionales
- Seiffe A., Ramírez M.F., Barrios C.D., Albarran M.M., Depino A.M. “Early estradiol exposure masculinizes disease-relevant behaviors in female mice.” European Journal of Neuroscience 53(8): 2483-2499 (Apr 2021). Epub 2021 Feb 23. doi: 10.1111/ejn.15130.
- Kazlauskas N, Seiffe A, Campolongo M, Zappala C, Depino AM. “Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism.” Psychoneuroendocrinology 110:104441 (Dec 2019). Epub 2019 Sep 11. doi: 10.1016/j.psyneuen.2019.104441.
- Graciarena M., Seiffe A., Nait-Oumesmar B., Depino A.M.. “Hypomyelination and Oligodendroglial Alterations in a Mouse Model of Autism Spectrum Disorder.” Frontiers in Cellular Neuroscience. 11;12:517 (Jan 2019). doi: 10.3389/fncel.2018.00517. eCollection 2018.
- Campolongo M., Kazlauskas N., Falasco G., Urrutia L., Salgueiro N., Höcht C.., Depino AM. “Sociability deficits after prenatal exposure to Valproic Acid are rescued by early social enrichment”, Molecular Autism 9:36 (Jun 2018). doi: 10.1186/s13229-018-0221-9. eCollection 2018.
- Depino A.M. “Perinatal inflammation and adult psychopathology: From preclinical models to humans”, Seminars in Cell & Developmental Biology. 77: 104-114 (May 2018). doi: 10.1016/j.semcdb.2017.09.010. Epub 2017 Sep 7. Artículo de revisión.
- Acosta J., Campolongo M.A., Höcht C., Depino A.M., Golombek D.A., Agostino P.V. “Deficits in temporal processing in mice prenatally exposed to Valproic Acid”, European Journal of Neuroscience. 47(6): 619-630 (2018). doi: 10.1111/ejn.13621.
- Kazlauskas N., Klappenbach M., Depino A.M.*, Locatelli F.F.* “Sickness behavior in honey bees”, Frontiers in Physiology, section Invertebrate Physiology, 7: 261(2016). (*co-autores corresponsales) doi: 10.3389/fphys.2016.00261.
- Kazlauskas N., Campolongo M., Lucchina L., Zappala C., Depino A.M. “Postnatal behavioural and inflammatory alterations in female pups prenatally exposed to valproic acid”, Psychoneuroendocrinology. 72: 11-21 (2016). doi: 10.1016/j.psyneuen.2016.06.001.
- Depino A.M. “Role of TGF-beta1 in the behavior disorders”, Advances in Neuroimmune Biology 6: 19-23 (2015).
- Depino A.M. “Early prenatal exposure to LPS results in anxiety and depression-related behaviors in adulthood”, Neuroscience 299: 56-65 (2015). doi: 10.1016/j.neuroscience.2015.04.065.
- Depino A.M. “Ciencia y ficción en la utilización terapéutica de las células madres”. Perspectivas Bioéticas. 19(35-36): 55-63 (2014).
- Lucchina L., Depino A.M. “Altered peripheral and central inflammatory responses in a mouse model of autism”. Autism Research. 7: 273-289 (2014). doi: 10.1002/aur.1338.
- Graciarena M., Roca V. Mathieu P., Depino A.M., Pitossi F.J. “Differential vulnerability of adult neurogenesis by adult and prenatal inflammation: Role of TGF-beta1”, Brain, Behavior and Immunity. 34: 17-28 (2013). doi: 10.1016/j.bbi.2013.05.007.
- Depino A.M. “Peripheral and central inflammation in autism spectrum disorders”, Molecular and Cellular Neuroscience 53: 69-76 (2013). Artículo de revisión. doi: 10.1016/j.mcn.2012.10.003
- Campolongo M., Benedetti L., Podhajcer O., Pitossi F., Depino A.M. “Hippocampal SPARC regulates depression-related behavior”. Genes, Brain and Behavior 11: 966-976 (2012). doi: 10.1111/j.1601-183X.2012.00848.x
- Depino A.M.*, Lucchina L., Pitossi F. ¨Early and adult hippocampal TGF-beta1 overexpression have opposite effects on behavior¨. Brain, Behavior and Immunity 25 (8): 1582-91 (2011). (*autor corresponsal). doi: 10.1016/j.bbi.2011.05.007
- Chertoff M., Di Paolo N., Schoeneberg A., Depino A., Ferrari C., Wurst W., Pfizenmaier K., Eisel U., Pitossi F. “Neuroprotective and neurodegenerative effects of the chronic expression of Tumor Necrosis Factor alpha in the nigrostriatal dopaminergic circuit of adult mice.” Experimental Neurology 227 (2): 237-51 (2011). doi: 10.1016/j.expneurol.2010.11.010
- Graciarena M., Depino A.M., Pitossi F. “Prenatal inflammation impairs adult neurogenesis and object recognition memory through TGF-β1” Brain, Behavior and Immunity 24 (8): 1301-9 (2010). doi: 10.1016/j.bbi.2010.06.005
- Lucchina L., Carola V., Pitossi F., Depino A.M. “Evaluating the interaction between postnatal inflammation and maternal care in the programming of adult anxiety and depression related behaviors.” Behavioural Brain Research 213 (1): 56-65 (2010). doi: 10.1016/j.bbr.2010.04.032
- Mathieu P., Battista D., Depino A., Roca V., Graciarena M., Pitossi F. ¨The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain¨. Journal of Neurochemistry 112: 1368-1385 (2010). Artículo de revisión. doi: 10.1111/j.1471-4159.2009.06548.x
- Depino A.M., Tsetsenis T., Gross C. ¨GABA homeostasis contributes to the developmental programming of anxiety-related behavior¨. Brain Research 1210: 189-99 (2008). doi: 10.1016/j.brainres.2008.03.006
- Depino A.M., Gross C. ¨Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice¨. Behavioural Brain Research 177: 154-160 (2007). doi: 10.1016/j.bbr.2006.11.025
- Depino A.M. “Maternal infection and the offspring brain”. The Journal of Neuroscience 26 (30): 7777-8 (2006). Artículo de revisión. doi: 10.1523/JNEUROSCI.2298-06.2006
- Ferrari C.C., Pott Godoy M.C., Tarelli R., Chertoff M., Depino A.M., Pitossi F.J. ¨Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra¨. Neurobiology of Disease 24 (1): 183-93 (2006). doi: 10.1016/j.nbd.2006.06.013
- Depino A., Ferrari C., Pott Godoy M.C., Tarelli R., Pitossi F.J. “Differential effects of interleukin-1beta on neurotoxicity, cytokine induction and glial reaction in specific brain regions”. Journal of Neuroimmunology 168 (1-2): 96-110 (2005). doi: 10.1016/j.jneuroim.2005.07.009
- Ferrari C.C., Depino A.M., Prada F., Muraro N., Campbell S., Podhajcer O., Perry V.H., Anthony D.C., Pitossi F.J. “Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain”. American Journal of Pathology 165(5):1827-37 (2004). doi: 10.1016/S0002-9440(10)63438-4
- Depino A.M.*, Alonso M., Ferrari C., del Rey A., Anthony D., Besedovsky H., Medina J.H., Pitossi F. ¨Learning modulation by endogenous hippocampal IL-1: blockade of endogenous IL-1 facilitates memory formation¨. Hippocampus 14 (4): 526-535 (2004) (*autor corresponsal). doi: 10.1002/hipo.10164
- Depino A.M., Earl C., Besedovsky H., del Rey A., Pitossi F., Oertel W.H. ¨Microglial activation with atypical pro-inflammatory cytokine expression in a rat model of Parkinson’s disease¨. European Journal of Neuroscience 18(10):2731-2742 (2003). doi: 10.1111/j.1460-9568.2003.03014.x
- Alonso M., Vianna M.R.M., Depino A.M., Mello e Souza T., Pereira P., Szapiro G., Viola H., Pitossi F.., Izquierdo I., Medina J.H. ¨Role of hippocampal BDNF during short and long-term memory formation¨. Hippocampus 12(4):551-560 (2002). doi: 10.1002/hipo.10035
- Alvarez M.J., Depino A.M., Podhajcer O.L., Pitossi F.J. ¨Bias in estimations of DNA content by competitive polymerase chain reaction¨. Analytical Biochemistry 287, No. 1, 87-94 (2000). doi: 10.1006/abio.2000.4823
En libros
- Kazlauskas N., Robinson-Agramonte M.A., Depino A.M. “Chapter 8: Neuroinflammation in Animal Models of Autism”. En Translational Approaches to Autism Sprectrum Disorder. ISBN 978-3-319-16320-8. Springer International Publishing Switzerland 2015.
- Depino A.M., Robinson-Agramonte M.A. “Chapter 9: Understanding on Neuroimmunology in Autism Sprectrum Disorder”. En Translational Approaches to Autism Sprectrum Disorder. ISBN 978-3-319-16320-8. Springer International Publishing Switzerland 2015.
- Luna, F., Salles, A., Arosteguy, J., Santi, M.F., Depino, A.M., Kusminsky, G. “Documento Nº3: Bancos de sangre de cordon umbilical. Observatorio Argentino de Bioética”, FLACSO, 2014, Argentina.
- Depino A., Mathieu P., Ferrari C., Pitossi F. Capítulo 8. “Respuesta inmunitaria en las enfermedades neurodegenerativas”. En Neuroinmunología Clínica., Jorge Correale, Andrés Villa, Orlando Garcea (Compiladores). ISBN: 978-950-06-0156-6. 468 páginas. Editorial Médica Panamericana, 2011, Buenos Aires.
- Depino A.M.. ¨Pro-inflammatory Cytokines in Learning and Memory¨. ISBN: 978-1-61668-626-0. 57 páginas. Nova Publishers, 2010, Nueva York, EEUU. Nota: Este libro es la publicación independiente del capítulo que sigue.
- Depino A.M.. Chapter 3. “Pro-inflammatory Cytokines in Learning and Memory”. En Learning and Memory Developments and Intellectual Disabilities. ISBN: 978-1-60876-397-9. Nova Publishers, 2011, EEUU.
- Pitossi F.J., Depino A., Di Paolo N. “Capítulo 56. Citocinas en el sistema nervioso central”. En Inmunopatología Molecular: Nuevas fronteras de la medicina. Un nexo entre la investigacion biomedica y la practica clinica, Rabinovich Gabriel Adrian (Compilador). ISBN: 950-06-1868-0. 614 páginas. Editorial Medica Panamericana, 2004, Madrid.
Congresos y reuniones científicas